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In the skin of the fruit, there is a large amount of a natural substance called Hydroxycitric Acid (HCA). This is the active ingredient in Garcinia Cambogia extract… that is, the substance that produces the weight loss effects. Bottom Line: Garcinia Cambogia is a plant often used in Asian recipes. The skin of the fruit contains a substance called Hydroxycitric Acid (HCA), which is the active ingredient.